Macaulay Culkin and Kieran Culkin Will Reunite Onscreen—Along With Their 3 Other Brothers

A Culkin family reunion is headed to the small screen.

After all, Kieran Culkin's real-life brothers Macaulay Culkin, Rory Culkin, Christian Culkin and Shane Culkin will play his brothers in his upcoming animated series, The Second Best Hospital in the Galaxy.

In the sixth episode of the Prime Video cartoon about alien doctors, which debuts Feb. 23, the Culkin brothers join in to celebrate a holiday—and reveal they are perhaps a little too close.

"We share everything," one of the brother's characters explains in a clip posted by Entertainment Weekly, "even digestive salivas."

The Culkin siblings even seemingly poked fun at their famously difficult childhood, with another brother saying a board game will "bring our happy childhood into our happy adulthood."

While the animated series marks the first time all five brothers are collaborating, they aren't strangers to working together.

Most notably, Kieran, 41, starred alongside Macaulay, 43, in the Home Alone movies, while Rory, 34, played younger versions of Macaulay in Richie Rich and Kiernan in Iggy Goes Down.

The show marks a return to acting for Christian, 37, and Shane, 48, who have mostly stayed out of the public eye over the years. Each of them have only claimed one acting credit: Christian in the 1994 film My Summer Story and Shane in the 1998 Broadway revival of Our Town.

In addition to the brothers, other Culkin siblings include sister Quinn Culkin, 39, as well as their late sister Dakota Culkin, who sadly died at the age of 30 after being struck by a car in 2008. Macaulay named his 2-year-old son Dakota—whom he shares with Brenda Song—in honor of his late sister.

The Culkins have been open about the difficulties they faced growing up in Hollywood, but Kieran admitted that no one had it harder than older brother Macaulay.

"Poor f--king guy. He was little and having to try to accept that level of fame as reality," he said in a March 2023 Esquire interview. "Even at that time, as a kid, I remember thinking, 'That sucks for him.'"

To learn about more famous Hollywood families, keep reading.

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The We're the Millers actress has the perfect mentor in the Pretty Woman star, who happens to be her auntie.

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The outspoken British singer is the older sister of the Game of Thrones star. She even wrote a song about him titled "Alfie."

 

The Damages star and the Lipstick Jungle actress are second cousins.

The Secret Life of Walter Mitty actress originally inspired her baby brother to get into show business.

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The Lost actor has a very famous cousin in the Mission: Impossible star.

The "Drop It Like It's Hot" rapper is first cousins with The Game actress and her brother, Ray J.